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The exogenous hyaluronic acid restores synovial balance.
The administration of exogenous HA increases the viscosity of the synovial fluid, restoring its lubricating, shock-absorbing and filtering properties.
Furthermore, it re-establishes the protective HA coating over the inner surface of the joint and increases the scavenging of free radicals.
As a result of these changes, inflammation of the synovium is reduced.
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The direct effects of exogenous HA cannot account for its long-term benefits, as each dose is cleared from the joint within a few days. It appears that, through its direct effects, exogenous HA restores the ability of the joint to produce its own HA, and thus returns it to a state of homeostasis that persists for several months. Evidence exists showing that HA may slow the destruction of cartilage.
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